منابع مشابه
Fabry Disease: New Therapeutic Approach
Fabry’s disease is an X-linked recessive lysosomal storage disorder that is caused by the deficient activity of the lysosomal α-galactosidase (α-GAL A). This results in the accumulation of globotriaosylceramide (GL3 or ceramide trihexoside, CTH) and related glycosphingolipids. In hemizygous male patients with the classic phenotype, levels of αGAL A activity are very low or undetectable. Patient...
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Evidence continues to accumulate on the importance of NO in angiogenesis.1–7 A number of angiogenic substances, including vascular endothelial growth factor (VEGF), stimulate production of NO in endothelial cells.8,9 In vivo biosynthesis of NO is essential for angiogenesis induced by tissue ischemia.3 Angiogenesis is severely impaired in ischemic hindlimb of endothelial NO synthase (eNOS)defici...
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Essential blepharospasm is a focal dystonia characterized by the involuntary and obliged closure of the eyes secondary to the contraction of the orbicular muscle and/or a dysfunction of the upper eyelid elevator muscle. The etiology of blepharospasm, which is more frequent in women between the fifth and seventh decade of life, is as yet unknown. Its diagnosis requires an in-depth ophthalmologic...
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Restoration of deoxyribonucleic acid in mitochondrial myopathies may occur after a mechanical or chemical injury of striated muscle or by endurance training. Therapies with enzymes, gene therapies, or treatments with substances that stimulate mitochondrial biogenesis are used at the moment. Genesis of mitochondria may also come from myonuclei by releasing the nuclear respiratory factor-1/2 duri...
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In the last decade, biologic agents, in particular infliximab and adalimum-ab, have deeply changed the therapeutic armamentarium of inflammatory bowel disease (IBD). However, these drugs have a number of contraindications and side-effects that physicians should know so to avoid and eventually manage them. Another important issue is the early introduction of immunomodulators and biologics in the...
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ژورنال
عنوان ژورنال: Deutsches Aerzteblatt Online
سال: 2012
ISSN: 1866-0452
DOI: 10.3238/arztebl.2012.0534b